The City of Arts and Sciences (CAC)—originally conceived as the "City of Sciences"—is an architectural, cultural, and entertainment complex in the city of Valencia. It also serves as the name of a neighborhood in Valencia, located within the Quatre Carreres district.

The complex was built during the 1990s and the early 2000s. Its final major component, the Palau de les Arts (Palace of the Arts), was inaugurated on October 9, 2005. The complex is situated at the end of the former Turia riverbed—a space converted into a public garden in the 1980s, following the river's diversion in the wake of the Great Flood of Valencia.

Santiago Calatrava served as the lead architect for the entire complex, with contributions from Félix Candela; the project is noted for its curvilinear architecture and the use of white concrete.

It consists of the following buildings: L'Hemisfèric, Museu de les Ciències Príncep Felip (Prince Felipe Science Museum), L'Umbracle, L'Oceanogràfic, Palau de les Arts Reina Sofia, l'Àgora and the Assut de l'Or Bridge.